› 2lri

Solution NMR

NMR structure of the second PHD finger of AIRE (AIRE-PHD2)

Released:
DOI: 10.2210/pdb2lri/pdb
PDB entry 2lri coloured by chain, ensemble of 50 models, front view.
PDB entry 2lri coloured by chain, ensemble of 50 models, side view.
PDB entry 2lri coloured by chain, ensemble of 50 models, top view.
Source organism: Homo sapiens
Primary publication:
AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.
Gaetani M, Matafora V, Saare M, Spiliotopoulos D, Mollica L, Quilici G, Chignola F, Mannella V, Zucchelli C, Peterson P, Bachi A, Musco G
Nucleic Acids Res 40 11756-68 (2012)
PMID: 23074189

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autoimmune regulator Chain: C
Molecule details ›
Chain: C
Length: 66 amino acids
Theoretical weight: 6.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43918 (Residues: 423-485; Coverage: 12%)
Gene names: AIRE, APECED
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 80%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

AIRE expands: new roles in immune tolerance and beyond.
Anderson et al. (2016)
10 more

4 mentions without citation

AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome.
Gaetani et al. (2012)
3 more