› 2lzk

Solution NMR

NMR solution structure of an N2-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing

Released:
DOI: 10.2210/pdb2lzk/pdb
PDB entry 2lzk coloured by chain, ensemble of 5 models, front view.
PDB entry 2lzk coloured by chain, ensemble of 5 models, side view.
PDB entry 2lzk coloured by chain, ensemble of 5 models, top view.
Source organism: Synthetic construct
Primary publication:
Nuclear magnetic resonance solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: intercalation from the minor groove with ruptured Watson-Crick base pairing.
Tang Y, Liu Z, Ding S, Lin CH, Cai Y, Rodriguez FA, Sayer JM, Jerina DM, Amin S, Broyde S, Geacintov NE
Biochemistry 51 9751-62 (2012)
PMID: 23121427

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115575 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*CP*CP*AP*TP*CP*GP*CP*TP*AP*CP*C)-3') Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.25 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*GP*GP*TP*AP*GP*CP*GP*AP*TP*GP*G)-3') Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.45 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand 14L 1 x 14L
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 29%
Refinement method: molecular dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
7 other articles

3 mentions without citation

The relationships between XPC binding to conformationally diverse DNA adducts and their excision by the human NER system: is there a correlation?
Lee et al. (2014)
2 more