› 2m0p

Solution NMR

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161358 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor-related protein 2 Chain: A
Molecule details ›
Chain: A
Length: 52 amino acids
Theoretical weight: 5.87 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P98164 (Residues: 1103-1148; Coverage: 1%)
Gene name: LRP2
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 87%
Refinement method: simulated annealing
Expression system: Komagataella pastoris

Quick links

Citations

5 review citations

Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?
Zavascki et al. (2017)
4 more

4 mentions without citation

Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin.
Dagil et al. (2013)
3 more