› 2m39

Solution NMR

The solution structure of 3',5'-LINKED 2'-O-(2-METHOXYETHYL)-RNA DUPLEX

Released:
DOI: 10.2210/pdb2m39/pdb
PDB entry 2m39 coloured by chain, ensemble of 9 models, front view.
PDB entry 2m39 coloured by chain, ensemble of 9 models, side view.
PDB entry 2m39 coloured by chain, ensemble of 9 models, top view.
Source organism: synthetic construct
Primary publication:
NMR structure of 2'-O-(2-methoxyethyl) modified and C5-methylated RNA dodecamer duplex.
Plevnik M, Cevec M, Plavec J
Biochimie 95 2385-91 (2013)
PMID: 24012551

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196489 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
RNA (5'-R(*(C5L)P*(G48)P*(C5L)P*(G48)P*(A44)P*(A44)P*(T39)P*(T39)P*(C5L)P*(G48)P*(C5L)P*DG)-3') Chains: A, B
Molecule details ›
Chains: A, B
Length: 12 nucleotides
Theoretical weight: 4.53 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
4 modified residues:
Ligand C5L 8 x C5L
Ligand G48 6 x G48
Ligand A44 4 x A44
Ligand T39 4 x T39

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 7%
Refinement method: simulated annealing, energy minimization
Expression system: Not provided

Quick links

Citations

2 citation in other articles

A two-residue nascent-strand steric gate controls synthesis of 2'-O-methyl- and 2'-O-(2-methoxyethyl)-RNA.
Freund et al. (2023)
1 more

1 mention without citation

Improving NMR Structures of RNA.
Bermejo et al. (2016)