› 2m5k

Hybrid

Atomic-resolution structure of a doublet cross-beta amyloid fibril

Released:
DOI: 10.2210/pdb2m5k/pdb
PDB entry 2m5k coloured by chain, front view.
PDB entry 2m5k coloured by chain, side view.
PDB entry 2m5k coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM
Proc Natl Acad Sci U S A 110 5468-73 (2013)
PMID: 23513222
Related structures: EMD-5590

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 912-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136175 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 11 amino acids
Theoretical weight: 1.2 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P02767 (Residues: 125-135; Coverage: 9%)
Gene names: Tt, Ttr

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Experimental Method: Solid-state NMR, Electron Microscopy
Resolution: 12.7Å
Relevant EMDB volumes: EMD-5590
Expression system: Not provided

Quick links

Citations

76 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
75 more

5 mentions without citation

Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Fitzpatrick et al. (2013)
4 more