› 2m6i

Solution NMR

Putative pentameric open-channel structure of full-length transmembrane domains of human glycine receptor alpha1 subunit

Released:
DOI: 10.2210/pdb2m6i/pdb
PDB entry 2m6i coloured by chain, ensemble of 15 models, front view.
PDB entry 2m6i coloured by chain, ensemble of 15 models, side view.
PDB entry 2m6i coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Open-channel structures of the human glycine receptor α1 full-length transmembrane domain.
Mowrey DD, Cui T, Jia Y, Ma D, Makhov AM, Zhang P, Tang P, Xu Y
Structure 21 1897-904 (2013)
PMID: 23994010

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149956 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycine receptor subunit alpha-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 150 amino acids
Theoretical weight: 17.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23415 (Residues: 244-453; Coverage: 33%)
Gene name: GLRA1
Sequence domains: Neurotransmitter-gated ion-channel transmembrane region
Structure domains: Neurotransmitter-gated ion-channel transmembrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 11%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels.
Sauguet et al. (2015)
2 more

5 mentions without citation

Structure and Pharmacologic Modulation of Inhibitory Glycine Receptors.
Burgos et al. (2016)
4 more