› 2ma9

Solution NMR

HIV-1 Vif SOCS-box and Elongin BC solution structure

Released:
DOI: 10.2210/pdb2ma9/pdb
PDB entry 2ma9 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ma9 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ma9 coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.
Lu Z, Bergeron JR, Atkinson RA, Schaller T, Veselkov DA, Oregioni A, Yang Y, Matthews SJ, Malim MH, Sanderson MR
Open Biol 3 130100 (2013)
PMID: 24225024

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-146245 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
p7 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.12 KDa
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Expression system: Escherichia coli
UniProt:
  • Canonical: P12504 (Residues: 139-174; Coverage: 19%)
Gene name: vif
Elongin-B Chain: B
Molecule details ›
Chain: B
Length: 118 amino acids
Theoretical weight: 13.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15370 (Residues: 1-118; Coverage: 100%)
Gene names: ELOB, TCEB2
Sequence domains: Ubiquitin family
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Elongin-C Chain: C
Molecule details ›
Chain: C
Length: 91 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15369 (Residues: 19-109; Coverage: 81%)
Gene names: ELOC, TCEB1
Sequence domains: Skp1 family, tetramerisation domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 27%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structural perspectives on HIV-1 Vif and APOBEC3 restriction factor interactions.
Azimi et al. (2020)
1 more

2 mentions without citation

Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.
Lu et al. (2013)
1 more