› 2mh5

Solution NMR

Structure and NMR assignments of lantibiotic NAI-107 in DPC micelles

Released:
DOI: 10.2210/pdb2mh5/pdb
PDB entry 2mh5 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mh5 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mh5 coloured by chain, ensemble of 20 models, top view.
Source organism: Microbispora sp. 107891
Primary publication:
The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.
Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R, Sahl HG
J Biol Chem 289 12063-12076 (2014)
PMID: 24627484

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160934 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lantibiotic 107891 Chain: A
Molecule details ›
Chain: A
Length: 24 amino acids
Theoretical weight: 2.24 KDa
Source organism: Microbispora sp. 107891
UniProt:
  • Canonical: P85065 (Residues: 1-24; Coverage: 100%)

Ligands and Environments

1 bound ligand:
Ligand DPV 65 x DPV
6 modified residues:
Ligand DBU 1 x DBU
Ligand DAL 4 x DAL
Ligand 5CW 1 x 5CW
Ligand DHA 1 x DHA
Ligand DBB 1 x DBB
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: molecular dynamics

Quick links

Citations

22 review citations

Regulation of antibiotic production in Actinobacteria: new perspectives from the post-genomic era.
van der Heul et al. (2018)
21 more

2 mentions without citation

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.
Münch et al. (2014)
1 more