› 2mi5

Solution NMR

Structure of insect-specific sodium channel toxin mu-Dc1a

Released:
DOI: 10.2210/pdb2mi5/pdb
PDB entry 2mi5 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mi5 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mi5 coloured by chain, ensemble of 20 models, top view.
Source organism: Diguetia canities
Primary publication:
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F
Nat Commun 5 4350 (2014)
PMID: 25014760

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155864 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-diguetoxin-Dc1a Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.5 KDa
Source organism: Diguetia canities
Expression system: Escherichia coli
UniProt:
  • Canonical: P49126 (Residues: 39-94; Coverage: 73%)
Sequence domains: Spider Toxins mu-diguetoxin-1 a, b and c
Structure domains: Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

10 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
9 more

1 mention without citation

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.
Bende et al. (2014)