› 2mnq

Solution NMR

1H, 13C, and 15N Chemical Shift Assignments for Thymosin alpha 1

Released:
DOI: 10.2210/pdb2mnq/pdb
PDB entry 2mnq coloured by chain, ensemble of 20 models, front view.
PDB entry 2mnq coloured by chain, ensemble of 20 models, side view.
PDB entry 2mnq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Thymosin α1 inserts N terminus into model membranes assuming a helical conformation.
Nepravishta R, Mandaliti W, Eliseo T, Sinibaldi Vallebona P, Pica F, Garaci E, Paci M
Expert Opin Biol Ther 15 Suppl 1 S71-81 (2015)
PMID: 25642593

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymosin alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 29 amino acids
Theoretical weight: 3.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06454 (Residues: 2-29; Coverage: 25%)
Gene names: PTMA, TMSA

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Thymosin alpha 1 and HIV-1: recent advances and future perspectives.
Matteucci et al. (2017)
2 more

1 mention without citation

Thymosin α1 and Its Role in Viral Infectious Diseases: The Mechanism and Clinical Application.
Tao et al. (2023)