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Solution NMR

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal Region of CCR3 Bound to CCL11/Eotaxin-1

Released:
DOI: 10.2210/pdb2mpm/pdb
PDB entry 2mpm coloured by chain, ensemble of 20 models, front view.
PDB entry 2mpm coloured by chain, ensemble of 20 models, side view.
PDB entry 2mpm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1.
Millard CJ, Ludeman JP, Canals M, Bridgford JL, Hinds MG, Clayton DJ, Christopoulos A, Payne RJ, Stone MJ
Structure 22 1571-81 (2014)
PMID: 25450766

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156395 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eotaxin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51671 (Residues: 24-97; Coverage: 100%)
Gene names: CCL11, SCYA11
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
CCR3 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand TYS 2 x TYS

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: torsion angle dynamics
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

9 review citations

The sweet spot: how GAGs help chemokines guide migrating cells.
Monneau et al. (2016)
8 more

8 mentions without citation

Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies.
Kufareva et al. (2015)
7 more