› 2mpq

Solution NMR

Solution structure of the sodium channel toxin Hd1a

Released:
DOI: 10.2210/pdb2mpq/pdb
PDB entry 2mpq coloured by chain, ensemble of 20 models, front view.
PDB entry 2mpq coloured by chain, ensemble of 20 models, side view.
PDB entry 2mpq coloured by chain, ensemble of 20 models, top view.
Source organism: Haplopelma
Primary publication:
Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF
Br J Pharmacol 172 2445-58 (2015)
PMID: 25754331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mu-theraphotoxin-Hd1a Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 3.89 KDa
Source organism: Haplopelma
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A0J9X1W9 (Residues: 1-35; Coverage: 100%)
Sequence domains: Ion channel inhibitory toxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

17 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
16 more

4 mentions without citation

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.
Klint et al. (2015)
3 more