› 2mwx

Solution NMR

The RING Domain of human Promyelocytic Leukemia Protein (PML)

Released:
DOI: 10.2210/pdb2mwx/pdb
PDB entry 2mwx coloured by chain, ensemble of 20 models, front view.
PDB entry 2mwx coloured by chain, ensemble of 20 models, side view.
PDB entry 2mwx coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The RING domain of human promyelocytic leukemia protein (PML).
Huang SY, Chang CF, Fang PJ, Naik MT, Güntert P, Shih HM, Huang TH
J Biomol NMR 61 173-80 (2015)
PMID: 25627356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151544 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein PML Chain: A
Molecule details ›
Chain: A
Length: 56 amino acids
Theoretical weight: 6.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29590 (Residues: 49-104; Coverage: 6%)
Gene names: MYL, PML, PP8675, RNF71, TRIM19
Sequence domains: Zinc finger, C3HC4 type (RING finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

1 review citation

PML Body Biogenesis: A Delicate Balance of Interactions.
Silonov et al. (2023)
2 other articles

1 mention without citation

Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases.
Fiorentini et al. (2020)