› 2mxy

Solution NMR

Solution structure of hnRNP C RRM in complex with 5'-AUUUUUC-3' RNA

Released:
DOI: 10.2210/pdb2mxy/pdb
PDB entry 2mxy coloured by chain, ensemble of 20 models, front view.
PDB entry 2mxy coloured by chain, ensemble of 20 models, side view.
PDB entry 2mxy coloured by chain, ensemble of 20 models, top view.
Source organisms:
Primary publication:
Structural and mechanistic insights into poly(uridine) tract recognition by the hnRNP C RNA recognition motif.
Cieniková Z, Damberger FF, Hall J, Allain FH, Maris C
J Am Chem Soc 136 14536-44 (2014)
PMID: 25216038

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139832 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct RNA molecule
Macromolecules (2 distinct):
Heterogeneous nuclear ribonucleoproteins C1/C2 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07910 (Residues: 2-106; Coverage: 34%)
Gene names: HNRNPC, HNRPC
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits
5'-R(*AP*UP*UP*UP*UP*UP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.12 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: simulated annealing, torsion angle dynamics
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

13 review citations

Recent advances in dynamic m6A RNA modification.
Cao et al. (2016)
12 more

3 mentions without citation

Amyloid Assembly Endows Gad m 1 with Biomineralization Properties.
Castellanos et al. (2018)
2 more