› 2myh

Solution NMR

Omega-Tbo-IT1: selective inhibitor of insect calcium channels isolated from Tibellus oblongus spider venom

Released:
DOI: 10.2210/pdb2myh/pdb
PDB entry 2myh coloured by chain, ensemble of 20 models, front view.
PDB entry 2myh coloured by chain, ensemble of 20 models, side view.
PDB entry 2myh coloured by chain, ensemble of 20 models, top view.
Source organism: Tibellus oblongus
Primary publication:
��-Tbo-IT1-New Inhibitor of Insect Calcium Channels Isolated from Spider Venom.
Mikov AN, Fedorova IM, Potapieva NN, Maleeva EE, Andreev YA, Zaitsev AV, Kim KK, Bocharov EV, Bozin TN, Altukhov DA, Lipkin AV, Kozlov SA, Tikhonov DB, Grishin EV
Sci Rep 5 17232 (2015)
PMID: 26611444

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-101355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Omega-phylotoxin-To1a Chain: A
Molecule details ›
Chain: A
Length: 41 amino acids
Theoretical weight: 4.35 KDa
Source organism: Tibellus oblongus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: A0A0G3F8Z3 (Residues: 39-79; Coverage: 71%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Fifty Years of Animal Toxin Research at the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS.
Tsetlin et al. (2023)
1 more

1 mention without citation

Structural analyses of the Haemophilus influenzae peptidoglycan synthase activator LpoA suggest multiple conformations in solution.
Sathiyamoorthy et al. (2017)