› 2n39

Solution NMR

NMR solution structure of a C-terminal domain of the chromodomain helicase DNA-binding protein 1

Released:
DOI: 10.2210/pdb2n39/pdb
PDB entry 2n39 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n39 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n39 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.
Mohanty B, Helder S, Silva AP, Mackay JP, Ryan DP
J Mol Biol 428 4298-4314 (2016)
PMID: 27591891

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127038 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chromodomain-helicase-DNA-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14646 (Residues: 1409-1511; Coverage: 6%)
Gene name: CHD1
Sequence domains: Chromodomain-helicase-DNA-binding protein 1-like, C-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: torsion angle dynamics, Water refinement
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer.
Clapier CR. (2021)
1 more

1 mention without citation

Structural reorganization of the chromatin remodeling enzyme Chd1 upon engagement with nucleosomes.
Sundaramoorthy et al. (2017)