› 2n3a

Solution NMR

Solution structure of LEDGF/p75 IBD in complex with POGZ peptide (1389-1404)

Released:
DOI: 10.2210/pdb2n3a/pdb
PDB entry 2n3a coloured by chain, ensemble of 29 models, front view.
PDB entry 2n3a coloured by chain, ensemble of 29 models, side view.
PDB entry 2n3a coloured by chain, ensemble of 29 models, top view.
Source organism: Homo sapiens
Primary publication:
Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.
Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P
Nat Commun 6 7968 (2015)
PMID: 26245978

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130988 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Pogo transposable element with ZNF domain Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q7Z3K3 (Residues: 1389-1404; Coverage: 1%)
Gene names: KIAA0461, Nbla00003, POGZ, SUHW5, ZNF280E, ZNF635
PC4 and SFRS1-interacting protein Chain: B
Molecule details ›
Chain: B
Length: 79 amino acids
Theoretical weight: 9.36 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O75475 (Residues: 348-426; Coverage: 15%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Structure domains: Conserved domain common to transcription factors TFIIS, elongin A, CRSP70

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Not provided

Quick links

Citations

11 review citations

Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins.
Li et al. (2021)
10 more