› 2n3x

Solution NMR

Solution Structure of TDP-43 Amyloidogenic Core Region

Released:
DOI: 10.2210/pdb2n3x/pdb
PDB entry 2n3x coloured by chain, ensemble of 10 models, front view.
PDB entry 2n3x coloured by chain, ensemble of 10 models, side view.
PDB entry 2n3x coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation.
Jiang LL, Zhao J, Yin XF, He WT, Yang H, Che MX, Hu HY
Sci Rep 6 23928 (2016)
PMID: 27030292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171557 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TAR DNA-binding protein 43 Chain: A
Molecule details ›
Chain: A
Length: 50 amino acids
Theoretical weight: 5.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13148 (Residues: 311-360; Coverage: 12%)
Gene names: TARDBP, TDP43
Sequence domains: TAR DNA-binding protein 43, C-terminal

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 64%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

14 review citations

TDP-43 proteinopathies: a new wave of neurodegenerative diseases.
de Boer et al. (2020)
13 more

9 mentions without citation

Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
Prasad et al. (2019)
8 more