› 2n6n

Solution NMR

Structure Determination for spider toxin, U4-agatoxin-Ao1a

Released:
DOI: 10.2210/pdb2n6n/pdb
PDB entry 2n6n coloured by chain, ensemble of 20 models, front view.
PDB entry 2n6n coloured by chain, ensemble of 20 models, side view.
PDB entry 2n6n coloured by chain, ensemble of 20 models, top view.
Source organism: Agelena orientalis
Primary publication:
Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene.
Pineda SS, Chin YK, Undheim EAB, Senff S, Mobli M, Dauly C, Escoubas P, Nicholson GM, Kaas Q, Guo S, Herzig V, Mattick JS, King GF
Proc Natl Acad Sci U S A 117 11399-11408 (2020)
PMID: 32398368

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
U4-agatoxin-Ao1a Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.43 KDa
Source organism: Agelena orientalis
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5Y4U5 (Residues: 37-68; Coverage: 74%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 92%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Animal toxins - Nature's evolutionary-refined toolkit for basic research and drug discovery.
Herzig et al. (2020)
9 more