› 2n90

Solution NMR

TrkA transmembrane domain NMR structure in DPC micelles

Released:
DOI: 10.2210/pdb2n90/pdb
PDB entry 2n90 coloured by chain, ensemble of 10 models, front view.
PDB entry 2n90 coloured by chain, ensemble of 10 models, side view.
PDB entry 2n90 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of the transmembrane domain dimerization and rotation in the activation mechanism of the TRKA receptor by nerve growth factor.
Franco ML, Nadezhdin KD, Goncharuk SA, Mineev KS, Arseniev AS, Vilar M
J Biol Chem 295 275-286 (2020)
PMID: 31801826

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138092 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 39 amino acids
Theoretical weight: 4.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04629 (Residues: 410-447; Coverage: 5%)
Gene names: MTC, NTRK1, TRK, TRKA
Sequence domains: Tyrosine kinase receptor A trans-membrane domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Receptor tyrosine kinase activation: From the ligand perspective.
Trenker et al. (2020)
1 more

5 mentions without citation

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors.
Casarotto et al. (2021)
4 more