› 2na9

Solution NMR

Transmembrane Structure of the P441A Mutant of the Cytokine Receptor Common Subunit beta

Released:
DOI: 10.2210/pdb2na9/pdb
PDB entry 2na9 coloured by chain, ensemble of 21 models, front view.
PDB entry 2na9 coloured by chain, ensemble of 21 models, side view.
PDB entry 2na9 coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
Schmidt T, Ye F, Situ AJ, An W, Ginsberg MH, Ulmer TS
J Biol Chem 291 17536-46 (2016)
PMID: 27365391

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152512 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytokine receptor common subunit beta Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 5.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32927 (Residues: 432-473; Coverage: 5%)
Gene names: CSF2RB, IL3RB, IL5RB

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 34%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

2 review citations

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11.
Metcalfe et al. (2020)
1 more

1 mention without citation

A Conserved Ectodomain-Transmembrane Domain Linker Motif Tunes the Allosteric Regulation of Cell Surface Receptors.
Schmidt et al. (2016)