› 2nef

Solution NMR

HIV-1 NEF (REGULATORY FACTOR), NMR, 40 STRUCTURES

Released:
DOI: 10.2210/pdb2nef/pdb
PDB entry 2nef coloured by chain, ensemble of 40 models, front view.
PDB entry 2nef coloured by chain, ensemble of 40 models, side view.
PDB entry 2nef coloured by chain, ensemble of 40 models, top view.
Source organism: Human immunodeficiency virus type 1 BH10
Primary publication:
Refined solution structure and backbone dynamics of HIV-1 Nef.
Grzesiek S, Bax A, Hu JS, Kaufman J, Palmer I, Stahl SJ, Tjandra N, Wingfield PT
Protein Sci 6 1248-63 (1997)
PMID: 9194185

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180644 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-terminal core protein Chain: A
Molecule details ›
Chain: A
Length: 136 amino acids
Theoretical weight: 16.15 KDa
Source organism: Human immunodeficiency virus type 1 BH10
Expression system: Escherichia coli
UniProt:
  • Canonical: Q70627 (Residues: 56-205; Coverage: 66%)
Gene name: nef
Sequence domains: Negative factor, (F-Protein) or Nef
Structure domains: Nef Regulatory Factor

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

13 review citations

HIV-1: fifteen proteins and an RNA.
Frankel et al. (1998)
12 more

31 mentions without citation

Mechanisms of HIV-1 Nef function and intracellular signaling.
Foster et al. (2011)
30 more