› 2nn2

X-ray diffraction
2.1Å resolution

Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator

Released:
DOI: 10.2210/pdb2nn2/pdb
PDB entry 2nn2 coloured by chain, front view.
PDB entry 2nn2 coloured by chain, side view.
PDB entry 2nn2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.
Stogios PJ, Chen L, Privé GG
Protein Sci 16 336-42 (2007)
PMID: 17189472

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-131900 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 7A Chains: A, B
Molecule details ›
Chains: A, B
Length: 133 amino acids
Theoretical weight: 14.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95365 (Residues: 1-131; Coverage: 22%)
Gene names: FBI1, LRF, ZBTB7, ZBTB7A, ZNF857A
Sequence domains: BTB/POZ domain
Structure domains: Potassium Channel Kv1.1; Chain A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P41212
Unit cell:
a: 72.143Å b: 72.143Å c: 116.048Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.267
Expression system: Escherichia coli

Quick links

Citations

4 review citations

POK/ZBTB proteins: an emerging family of proteins that regulate lymphoid development and function.
Lee et al. (2012)
3 more

8 mentions without citation

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains.
Ogura et al. (2010)
7 more