› 2nna

X-ray diffraction
2.1Å resolution

Structure of the MHC class II molecule HLA-DQ8 bound with a deamidated gluten peptide

Released:
DOI: 10.2210/pdb2nna/pdb
PDB entry 2nna coloured by chain, front view.
PDB entry 2nna coloured by chain, side view.
PDB entry 2nna coloured by chain, top view.
Source organisms:
Primary publication:
A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease.
Henderson KN, Tye-Din JA, Reid HH, Chen Z, Borg NA, Beissbarth T, Tatham A, Mannering SI, Purcell AW, Dudek NL, van Heel DA, McCluskey J, Rossjohn J, Anderson RP
Immunity 27 23-34 (2007)
PMID: 17629515

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135364 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class II histocompatibility antigen, DQ alpha 1 chain Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 21.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01909 (Residues: 24-78, 79-206; Coverage: 79%)
Gene name: HLA-DQA1
Sequence domains:
Structure domains:
HLA class II histocompatibility antigen, DQ beta 1 chain Chain: B
Molecule details ›
Chain: B
Length: 207 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P01920 (Residues: 33-224; Coverage: 84%)
Gene names: HLA-DQB, HLA-DQB1
Sequence domains:
Structure domains:
Alpha/beta-gliadin MM1 Chain: C
Molecule details ›
Chain: C
Length: 18 amino acids
Theoretical weight: 2.01 KDa
Source organism: Triticum aestivum
Expression system: Not provided
UniProt:
  • Canonical: P18573 (Residues: 243-260; Coverage: 6%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 58.83Å b: 92.52Å c: 113.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.248
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

40 review citations

Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
Abadie et al. (2011)
39 more

28 mentions without citation

Role of transglutaminase 2 in celiac disease pathogenesis.
Klöck et al. (2012)
27 more