› 2nqc

X-ray diffraction
2.05Å resolution

Crystal structure of ig-like domain 23 from human filamin C

Released:
DOI: 10.2210/pdb2nqc/pdb
PDB entry 2nqc coloured by chain, front view.
PDB entry 2nqc coloured by chain, side view.
PDB entry 2nqc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.
Sjekloća L, Pudas R, Sjöblom B, Konarev P, Carugo O, Rybin V, Kiema TR, Svergun D, Ylänne J, Djinović Carugo K
J Mol Biol 368 1011-23 (2007)
PMID: 17379241

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171988 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-C Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14315 (Residues: 2495-2598; Coverage: 4%)
Gene names: ABPL, FLN2, FLNC
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:
Ligand NI 1 x NI
Ligand IMD 2 x IMD
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P3121
Unit cell:
a: 52.141Å b: 52.141Å c: 69.216Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.19 0.188 0.237
Expression system: Escherichia coli

Quick links

Citations

2 review citations

When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies.
Ehsan et al. (2017)
1 more

4 mentions without citation

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.
Nakamura et al. (2009)
3 more