› 2nt2

X-ray diffraction
2.1Å resolution

Crystal Structure of Slingshot phosphatase 2

Released:
DOI: 10.2210/pdb2nt2/pdb
PDB entry 2nt2 coloured by chain, front view.
PDB entry 2nt2 coloured by chain, side view.
PDB entry 2nt2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human slingshot phosphatase 2.
Jung SK, Jeong DG, Yoon TS, Kim JH, Ryu SE, Kim SJ
Proteins 68 408-12 (2007)
PMID: 17427953

Function and Biology Details

Reactions catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein phosphatase Slingshot homolog 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 145 amino acids
Theoretical weight: 17.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q76I76 (Residues: 305-448; Coverage: 10%)
Gene names: KIAA1725, SSH2, SSH2L
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P32
Unit cell:
a: 94.58Å b: 94.58Å c: 38.77Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.144 0.142 0.174
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation.
Mizuno K. (2013)
1 more

4 mentions without citation

Critical Roles of Dual-Specificity Phosphatases in Neuronal Proteostasis and Neurological Diseases.
Bhore et al. (2017)
3 more