› 2nzi

X-ray diffraction
2.9Å resolution

Crystal structure of domains A168-A170 from titin

Released:
DOI: 10.2210/pdb2nzi/pdb
PDB entry 2nzi coloured by chain, front view.
PDB entry 2nzi coloured by chain, side view.
PDB entry 2nzi coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular determinants for the recruitment of the ubiquitin-ligase MuRF-1 onto M-line titin.
Mrosek M, Labeit D, Witt S, Heerklotz H, von Castelmur E, Labeit S, Mayans O
FASEB J 21 1383-92 (2007)
PMID: 17215480

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chains: A, B
Molecule details ›
Chains: A, B
Length: 305 amino acids
Theoretical weight: 33.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WZ42 (Residues: 31854-32155; Coverage: 1%)
Gene name: TTN
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P3121
Unit cell:
a: 125.89Å b: 125.89Å c: 134.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.219 0.274
Expression system: Escherichia coli

Quick links

Citations

19 review citations

Muscle giants: molecular scaffolds in sarcomerogenesis.
Kontrogianni-Konstantopoulos et al. (2009)
18 more

11 mentions without citation

Cytoplasmic Ig-domain proteins: cytoskeletal regulators with a role in human disease.
Otey et al. (2009)
10 more