› 2nzt

X-ray diffraction
2.45Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + D-hexose = ADP + D-hexose 6-phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156639 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexokinase-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 902 amino acids
Theoretical weight: 100.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P52789 (Residues: 17-916; Coverage: 98%)
Gene name: HK2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GLC 4 x GLC
Ligand BG6 4 x BG6
Ligand UNX 28 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P212121
Unit cell:
a: 94.89Å b: 129.338Å c: 187.232Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.287
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The Warburg Effect 97 Years after Its Discovery.
Pascale et al. (2020)
2 more

27 mentions without citation

Sugar for the brain: the role of glucose in physiological and pathological brain function.
Mergenthaler et al. (2013)
26 more