2o39

X-ray diffraction
2.85Å resolution

Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-147395 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Fiber protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 197 amino acids
Theoretical weight: 22.05 KDa
Source organism: Human adenovirus 11p
Expression system: Escherichia coli
UniProt:
  • Canonical: P35774 (Residues: 129-325; Coverage: 61%)
Gene name: L5
Sequence domains: Adenoviral fibre protein (knob domain)
Structure domains: Adenovirus pIV-related, attachment domain
Membrane cofactor protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 126 amino acids
Theoretical weight: 14.52 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P15529 (Residues: 35-160; Coverage: 35%)
Gene names: CD46, MCP, MIC10
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P3
Unit cell:
a: 106.14Å b: 106.14Å c: 68.32Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.238 0.238 0.273
Expression systems:
  • Escherichia coli
  • Cricetulus griseus