› 2obe

X-ray diffraction
2.1Å resolution

Crystal Structure of Chimpanzee Adenovirus (Type 68/Simian 25) Major Coat Protein Hexon

Released:
DOI: 10.2210/pdb2obe/pdb
PDB entry 2obe coloured by chain, front view.
PDB entry 2obe coloured by chain, side view.
PDB entry 2obe coloured by chain, top view.
Source organism: Simian adenovirus 25
Primary publication:
Structure-based identification of a major neutralizing site in an adenovirus hexon.
Pichla-Gollon SL, Drinker M, Zhou X, Xue F, Rux JJ, Gao GP, Wilson JM, Ertl HC, Burnett RM, Bergelson JM
J Virol 81 1680-9 (2007)
PMID: 17108028

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186532 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hexon protein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 932 amino acids
Theoretical weight: 104.89 KDa
Source organism: Simian adenovirus 25
UniProt:
  • Canonical: Q8UY79 (Residues: 2-933; Coverage: 100%)
Gene name: L3
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 2HP 22 x 2HP
Ligand MPD 24 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: C222
Unit cell:
a: 90.8Å b: 433Å c: 159.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.169 0.21

Quick links

Citations

15 review citations

Pre-existing immunity against Ad vectors: humoral, cellular, and innate response, what's important?.
Fausther-Bovendo et al. (2014)
14 more

7 mentions without citation

Structure-based identification of a major neutralizing site in an adenovirus hexon.
Pichla-Gollon et al. (2007)
6 more