› 2od1

Solution NMR

Solution structure of the MYND domain from human AML1-ETO

Released:
DOI: 10.2210/pdb2od1/pdb
PDB entry 2od1 coloured by chain, ensemble of 31 models, front view.
PDB entry 2od1 coloured by chain, ensemble of 31 models, side view.
PDB entry 2od1 coloured by chain, ensemble of 31 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for recognition of SMRT/N-CoR by the MYND domain and its contribution to AML1/ETO's activity.
Liu Y, Chen W, Gaudet J, Cheney MD, Roudaia L, Cierpicki T, Klet RC, Hartman K, Laue TM, Speck NA, Bushweller JH
Cancer Cell 11 483-97 (2007)
PMID: 17560331

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170346 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q06455 (Residues: 510-559; Coverage: 8%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: MYND finger
Structure domains: Helix Hairpins

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

16 review citations

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.
Taverna et al. (2007)
15 more

3 mentions without citation

Novel RNA-binding properties of the MTG chromatin regulatory proteins.
Rossetti et al. (2008)
2 more