PDB 2og8 biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Tyrosine-protein kinase Lck
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Multimeric state: monomeric

Accessible surface area: 11974.85 Å²

Buried surface area: 1186.84 Å²

Dissociation area: 593.42 Å²

Dissociation energy (ΔG^diss): -6.34 kcal/mol

Dissociation entropy (TΔS^diss): 6.03 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-138948

$Monomeric assembly 1 of PDB entry 2og8 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2og8 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 2og8 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Tyrosine-protein kinase Lck
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Multimeric state: monomeric

Accessible surface area: 12106.08 Å²

Buried surface area: 1196.5 Å²

Dissociation area: 598.25 Å²

Dissociation energy (ΔG^diss): -6.87 kcal/mol

Dissociation entropy (TΔS^diss): 6.03 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-138948

$Monomeric assembly 2 of PDB entry 2og8 coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2og8 coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 2og8 coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Tyrosine-protein kinase Lck;</li> <li class='image_legend_li'>1 copy of N-{2-[(N,N-DIETHYLGLYCYL)AMINO]-5-(TRIFLUOROMETHYL)PHENYL}-4-METHYL-3-[2-(METHYLAMINO)QUINAZOLIN-6-YL]BENZAMIDE;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Tyrosine-protein kinase Lck

Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.52 KDa
Source organism: Homo sapiens
Expression system: Insect Cell
UniProt:

Canonical: P06239 (Residues: 237-499; Coverage: 52%)

Gene name: LCK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:

Protein kinase-like domain superfamily
Protein kinase domain
Serine-threonine/tyrosine-protein kinase, catalytic domain
Tyrosine-protein kinase, catalytic domain
Protein kinase, ATP binding site
Tyrosine-protein kinase, active site

CATH:

Phosphorylase Kinase; domain 1
Transferase(Phosphotransferase) domain 1

SCOP: Protein kinases, catalytic subunit

Tyrosine-protein kinase Lck in PDB entry 2og8, assembly 1, front view.

Tyrosine-protein kinase Lck in PDB entry 2og8, assembly 1, side view.

Tyrosine-protein kinase Lck in PDB entry 2og8, assembly 1, top view.

FASTA Sequence


    >pdb|2og8|A B

DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTA

PDBe-KB: UniProt Coverage View: P06239

Molecule details ›

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FASTA (Protein chains A, B)
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SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
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BLAST P06239 (UniProt)

Protein Data Bank in Europe

crystal structure of aminoquinazoline 36 bound to Lck

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 2og8 › Structure analysis

crystal structure of aminoquinazoline 36 bound to Lck

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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2og8 › Structure analysis