› 2ogv

X-ray diffraction
2.7Å resolution

Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain

Released:
DOI: 10.2210/pdb2ogv/pdb
PDB entry 2ogv coloured by chain, front view.
PDB entry 2ogv coloured by chain, side view.
PDB entry 2ogv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.
Walter M, Lucet IS, Patel O, Broughton SE, Bamert R, Williams NK, Fantino E, Wilks AF, Rossjohn J
J Mol Biol 367 839-47 (2007)
PMID: 17292918

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139513 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage colony-stimulating factor 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 317 amino acids
Theoretical weight: 35.79 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07333 (Residues: 543-918; Coverage: 33%)
Gene names: CSF1R, FMS
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21212
Unit cell:
a: 104.253Å b: 57.298Å c: 56.785Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.206 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

11 review citations

CSF-1 receptor signaling in myeloid cells.
Stanley et al. (2014)
10 more

8 mentions without citation

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms.
Durham et al. (2019)
7 more