› 2ooq

X-ray diffraction
1.8Å resolution

Crystal Structure of the Human Receptor Phosphatase PTPRT

Released:
DOI: 10.2210/pdb2ooq/pdb
PDB entry 2ooq coloured by chain, front view.
PDB entry 2ooq coloured by chain, side view.
PDB entry 2ooq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Barr AJ, Ugochukwu E, Lee WH, King ON, Filippakopoulos P, Alfano I, Savitsky P, Burgess-Brown NA, Müller S, Knapp S
Cell 136 352-63 (2009)
PMID: 19167335

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126994 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein phosphatase T Chains: A, B
Molecule details ›
Chains: A, B
Length: 286 amino acids
Theoretical weight: 32.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14522 (Residues: 868-1151; Coverage: 20%)
Gene names: KIAA0283, PTPRT
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

3 bound ligands:
Ligand B3P 2 x B3P
Ligand NA 1 x NA
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 37.186Å b: 86.697Å c: 91.12Å
α: 90° β: 99.89° γ: 90°
R-values:
R R work R free
0.147 0.145 0.188
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Inside the human cancer tyrosine phosphatome.
Julien et al. (2011)
58 more

4 mentions without citation

Analysis and Interpretation of the Impact of Missense Variants in Cancer.
Petrosino et al. (2021)
3 more