Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149098 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein kinase ZAP-70
Molecule details ›
Chain: A
Length: 254 amino acids
Theoretical weight: 28.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains:
Length: 254 amino acids
Theoretical weight: 28.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P43403 (Residues: 3-256; Coverage: 41%)
Sequence domains: SH2 domain
Structure domains:
T-cell surface glycoprotein CD3 zeta chain
Molecule details ›
Chain: B
Length: 19 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: Immunoreceptor tyrosine-based activation motif
Length: 19 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical: P20963 (Residues: 69-87; Coverage: 13%)
Sequence domains: Immunoreceptor tyrosine-based activation motif
