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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

X-ray diffraction
1.9Å resolution
PDB entry 2oq1 coloured by chain, front view.
PDB entry 2oq1 coloured by chain, side view.
PDB entry 2oq1 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: T-cell surface glycoprotein CD3 zeta chain and Tyrosine-protein kinase ZAP-70
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Multimeric state: hetero dimer
Accessible surface area: 13865.47 Å2
Buried surface area: 2547.03 Å2
Dissociation area: 1,205.45 Å2
Dissociation energy (ΔGdiss): 14.06 kcal/mol
Dissociation entropy (TΔSdiss): 9.74 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-149098

Macromolecules

Tyrosine-protein kinase ZAP-70
Chain: A
Length: 254 amino acids
Theoretical weight: 28.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43403 (Residues: 3-256; Coverage: 41%)
Gene names: SRK, ZAP70
Pfam: SH2 domain
InterPro:
CATH:
SCOP: SH2 domain
Tyrosine-protein kinase ZAP-70 in PDB entry 2oq1, assembly 1, front view.
Tyrosine-protein kinase ZAP-70 in PDB entry 2oq1, assembly 1, side view.
Tyrosine-protein kinase ZAP-70 in PDB entry 2oq1, assembly 1, top view.
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T-cell surface glycoprotein CD3 zeta chain
Chain: B
Length: 19 amino acids
Theoretical weight: 2.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20963 (Residues: 69-87; Coverage: 13%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Pfam: Immunoreceptor tyrosine-based activation motif
InterPro: Phosphorylated immunoreceptor signalling ITAM
T-cell surface glycoprotein CD3 zeta chain in PDB entry 2oq1, assembly 1, front view.
T-cell surface glycoprotein CD3 zeta chain in PDB entry 2oq1, assembly 1, side view.
T-cell surface glycoprotein CD3 zeta chain in PDB entry 2oq1, assembly 1, top view.
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