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Tandem SH2 domains of ZAP-70 with 19-mer zeta1 peptide

Source organism: Homo sapiens
Biochemical function: transmembrane signaling receptor activity
Biological process: cell surface receptor signaling pathway
Cellular component: membrane

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EC 2.7.10.2: Non-specific protein-tyrosine kinase

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Systematic name:
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Alternative Name(s):
  • ABL
  • ABL1
  • ABL2
  • ABLL
  • ACK1
  • ACK2
  • AGMX1
  • ARG
  • ATK
  • ATP:protein-tyrosine O-phosphotransferase
  • BLK
  • BMX
  • BRK
  • BTK
  • BTKL
  • Bmk
  • Bruton's tyrosine kinase
  • Bsk
  • CAKb
  • CHK
  • CSK
  • CTK
  • CYL
  • Cdgip
  • Cytoplasmic protein tyrosine kinase
  • EMT
  • ETK
  • FAK
  • FAK2
  • FER
  • FES
  • FGR
  • FPS
  • FRK
  • FYN
  • Fadk
  • Fert1/2
  • Focal adhesion kinase
  • HCK
  • HCTK
  • HYL
  • IMD1
  • ITK
  • IYK
  • JAK1
  • JAK2
  • JAK3
  • JTK1
  • JTK9
  • Janus kinase 1
  • Janus kinase 2
  • Janus kinase 3
  • L-JAK
  • LCK
  • LSK
  • LYN
  • MATK
  • Ntk
  • P60c-src protein tyrosine kinase
  • PKB
  • PSCTK
  • PSCTK1
  • PSCTK2
  • PSCTK4
  • PSCTK5
  • PTK2
  • PTK2B
  • PTK6
  • PYK2
  • Protein-tyrosine kinase
  • RAFTK
  • RAK
  • Rlk
  • SLK
  • SRC
  • SRC2
  • SRK
  • SRM
  • SRMS
  • STD
  • SYK
  • SYN
  • Sik
  • TEC
  • TNK1
  • TXK
  • TYK2
  • TYK3
  • Tck
  • Tsk
  • YES1
  • YK2
  • ZAP70

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00017
Domain description: SH2 domain
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
The deposited structure of PDB entry 2oq1 contains 2 copies of Pfam domain PF00017 (SH2 domain) in Tyrosine-protein kinase ZAP-70. Showing 2 copies in chain A.

PF02189
Domain description: Immunoreceptor tyrosine-based activation motif
Occurring in:
  1. T-cell surface glycoprotein CD3 zeta chain
The deposited structure of PDB entry 2oq1 contains 1 copy of Pfam domain PF02189 (Immunoreceptor tyrosine-based activation motif) in T-cell surface glycoprotein CD3 zeta chain. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000980
Domain description: SH2 domain
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
IPR036860
Domain description: SH2 domain superfamily
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
IPR003110
Domain description: Phosphorylated immunoreceptor signalling ITAM
Occurring in:
  1. T-cell surface glycoprotein CD3 zeta chain
IPR023420
Domain description: Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
IPR035838
Domain description: SYK/ZAP-70, N-terminal SH2 domain
Occurring in:
  1. Tyrosine-protein kinase ZAP-70

Structure domains

CATH CATH domains
3.30.505.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: SHC Adaptor Protein
Homology: SH2 domain
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
The deposited structure of PDB entry 2oq1 contains 2 copies of CATH domain 3.30.505.10 (SHC Adaptor Protein) in Tyrosine-protein kinase ZAP-70. Showing 2 copies in chain A.
1.10.930.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Syk Kinase; Chain A, domain 2
Homology: Syk Kinase; Chain A, domain 2
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
The deposited structure of PDB entry 2oq1 contains 1 copy of CATH domain 1.10.930.10 (Syk Kinase; Chain A, domain 2) in Tyrosine-protein kinase ZAP-70. Showing 1 copy in chain A.
SCOP SCOP annotation
55551
Class: Alpha and beta proteins (a+b)
Fold: SH2-like
Superfamily: SH2 domain
Occurring in:
  1. Tyrosine-protein kinase ZAP-70
The deposited structure of PDB entry 2oq1 contains 2 copies of SCOP domain 55551 (SH2 domain) in Tyrosine-protein kinase ZAP-70. Showing 2 copies in chain A.

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