› 2ose

X-ray diffraction
2.04Å resolution

Crystal Structure of the Mimivirus Cyclophilin

Released:
DOI: 10.2210/pdb2ose/pdb
PDB entry 2ose coloured by chain, front view.
PDB entry 2ose coloured by chain, side view.
PDB entry 2ose coloured by chain, top view.
Source organism: Mimivirus
Primary publication:
Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus.
Thai V, Renesto P, Fowler CA, Brown DJ, Davis T, Gu W, Pollock DD, Kern D, Raoult D, Eisenmesser EZ
J Mol Biol 378 71-86 (2008)
PMID: 18342330

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178375 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Structural PPIase-like protein L605 Chain: A
Molecule details ›
Chain: A
Length: 234 amino acids
Theoretical weight: 26.57 KDa
Source organism: Mimivirus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5UP71 (Residues: 1-234; Coverage: 100%)
Gene name: MIMI_L605
Sequence domains: Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
Structure domains: Cyclophilin-like

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P213
Unit cell:
a: 95.032Å b: 95.032Å c: 95.032Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.255
Expression system: Escherichia coli

Quick links

Citations

11 review citations

The rapidly expanding universe of giant viruses: Mimivirus, Pandoravirus, Pithovirus and Mollivirus.
Abergel et al. (2015)
10 more

3 mentions without citation

Role of the GTNGTKR motif in the N-terminal receptor-binding domain of the SARS-CoV-2 spike protein.
Behloul et al. (2020)
2 more