› 2oxc

X-ray diffraction
1.3Å resolution

Human DEAD-box RNA helicase DDX20, DEAD domain in complex with ADP

Released:
DOI: 10.2210/pdb2oxc/pdb
PDB entry 2oxc coloured by chain, front view.
PDB entry 2oxc coloured by chain, side view.
PDB entry 2oxc coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Karlberg T, Ogg D, Arrowsmith CH, Berglund H, Busam RD, Collins R, Dahlgren LG, Edwards A, Flodin S, Flores A, Graslund S, Hallberg BM, Hammarstrom M, Hogbom M, Johansson I, Kotenyova T, Lehtio L, Moche M, Nordlund P, Nyman T, Persson C, Sagemark J, Stenmark P, Sundstrom M, Thorsell AG, Van Den Berg S, Weigelt J, Holmberg-Schiavone L, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193750 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable ATP-dependent RNA helicase DDX20 Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UHI6 (Residues: 41-268; Coverage: 28%)
Gene names: DDX20, DP103, GEMIN3
Sequence domains: DEAD/DEAH box helicase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand ADP 2 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P3121
Unit cell:
a: 63.8Å b: 63.8Å c: 214.3Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.154 0.153 0.175
Expression system: Escherichia coli

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