Function and Biology Details
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Mitogen-activated protein (MAP) kinase p38-like
- Protein kinase domain
- Protein kinase, ATP binding site
- Protein kinase-like domain superfamily
- Mitogen-activated protein (MAP) kinase, conserved site
- Mitogen-activated protein kinase 14
- MAP kinase activated protein kinase, C-terminal
- Serine/threonine-protein kinase, active site
Structure domain:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155651 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MAP kinase-activated protein kinase 2
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 356 amino acids
Theoretical weight: 40.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P49137 (Residues: 47-400; Coverage: 89%)
Sequence domains: Protein kinase domain
Structure domains:
Mitogen-activated protein kinase 14
Molecule details ›
Chain: B
Length: 366 amino acids
Theoretical weight: 42.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains: Protein kinase domain
Structure domains:
Length: 366 amino acids
Theoretical weight: 42.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical: P47811 (Residues: 2-360; Coverage: 100%)
Sequence domains: Protein kinase domain
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
APS BEAMLINE 31-ID
Spacegroup:
P41212
Expression system: Escherichia coli BL21(DE3)
