› 2p2r

X-ray diffraction
1.6Å resolution

Crystal structure of the third KH domain of human Poly(C)-Binding Protein-2 in complex with C-rich strand of human telomeric DNA

Released:
DOI: 10.2210/pdb2p2r/pdb
PDB entry 2p2r coloured by chain, front view.
PDB entry 2p2r coloured by chain, side view.
PDB entry 2p2r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the third KH domain of human poly(C)-binding protein-2 in complex with a C-rich strand of human telomeric DNA at 1.6 A resolution.
Fenn S, Du Z, Lee JK, Tjhen R, Stroud RM, James TL
Nucleic Acids Res 35 2651-60 (2007)
PMID: 17426136

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-115750 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Poly(rC)-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 76 amino acids
Theoretical weight: 8.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q15366 (Residues: 285-359; Coverage: 21%)
Gene name: PCBP2
Sequence domains: KH domain
Structure domains: K Homology domain, type 1
C-rich strand of human telomeric DNA Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.07 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand CYT 1 x CYT
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: R32
Unit cell:
a: 81.069Å b: 81.069Å c: 87.815Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.205 0.242
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

5 review citations

Structure and function of KH domains.
Valverde et al. (2008)
4 more

13 mentions without citation

Management versus miscues in the cytosolic labile iron pool: The varied functions of iron chaperones.
Philpott et al. (2020)
12 more