› 2p4d

X-ray diffraction
1.8Å resolution

Structure-assisted discovery of Variola major H1 phosphatase inhibitors

Released:
DOI: 10.2210/pdb2p4d/pdb
PDB entry 2p4d coloured by chain, front view.
PDB entry 2p4d coloured by chain, side view.
PDB entry 2p4d coloured by chain, top view.
Source organism: Variola virus
Primary publication:
Structure-assisted discovery of Variola major H1 phosphatase inhibitors.
Phan J, Tropea JE, Waugh DS
Acta Crystallogr D Biol Crystallogr 63 698-704 (2007)
PMID: 17505108

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-163140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 20.24 KDa
Source organism: Variola virus
Expression system: Escherichia coli BL21(DE3)
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: I4122
Unit cell:
a: 101.441Å b: 101.441Å c: 95.101Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Protein tyrosine phosphatase structure-function relationships in regulation and pathogenesis.
Böhmer et al. (2013)
9 other articles

3 mentions without citation

Poxvirus proteomics and virus-host protein interactions.
Van Vliet et al. (2009)
2 more