› 2pa1

X-ray diffraction
1.7Å resolution

Structure of the PDZ domain of human PDLIM2 bound to a C-terminal extension from human beta-tropomyosin

Released:
DOI: 10.2210/pdb2pa1/pdb
PDB entry 2pa1 coloured by chain, front view.
PDB entry 2pa1 coloured by chain, side view.
PDB entry 2pa1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins JM, Gileadi C, Shrestha L, Phillips C, Wang J, Muniz JR, Doyle DA
Protein Sci 19 731-41 (2010)
PMID: 20120020

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188591 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PDZ and LIM domain protein 2 Chain: A
Molecule details ›
Chain: A
Length: 87 amino acids
Theoretical weight: 9.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96JY6 (Residues: 1-82; Coverage: 23%)
Gene names: PDLIM2, PP6345
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 58.77Å b: 58.77Å c: 52.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.253
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
4 more

2 mentions without citation

Unusual binding interactions in PDZ domain crystal structures help explain binding mechanisms.
Elkins et al. (2010)
1 more