Function and Biology Details
Reaction catalysed:
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- Aromatic amino acid hydroxylase, C-terminal
- Aromatic amino acid hydroxylase, iron/copper binding site
- Eukaryotic phenylalanine-4-hydroxylase, catalytic domain
- Aromatic amino acid hydroxylase superfamily
- Aromatic amino acid monoxygenase, C-terminal domain superfamily
- Phenylalanine-4-hydroxylase, tetrameric form
- Aromatic amino acid hydroxylase
Structure domain:
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
Phenylalanine-4-hydroxylase (preferred)
PDBe Complex ID:
PDB-CPX-132488 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phenylalanine-4-hydroxylase
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Structure domains: Aromatic amino acid hydroxylase
Length: 335 amino acids
Theoretical weight: 38.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
- Canonical:
P00439 (Residues: 118-452; Coverage: 74%)
Sequence domains: Biopterin-dependent aromatic amino acid hydroxylase
Structure domains: Aromatic amino acid hydroxylase
