› 2pk4

X-ray diffraction
2.25Å resolution

THE REFINED STRUCTURE OF THE EPSILON-AMINOCAPROIC ACID COMPLEX OF HUMAN PLASMINOGEN KRINGLE

Released:
DOI: 10.2210/pdb2pk4/pdb
PDB entry 2pk4 coloured by chain, front view.
PDB entry 2pk4 coloured by chain, side view.
PDB entry 2pk4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.
Wu TP, Padmanabhan K, Tulinsky A, Mulichak AM
Biochemistry 30 10589-94 (1991)
PMID: 1657149

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Angiostatin Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 9.17 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00747 (Residues: 375-454; Coverage: 10%)
Gene name: PLG
Sequence domains: Kringle domain
Structure domains: Plasminogen Kringle 4

Ligands and Environments

1 bound ligand:
Ligand ACA 1 x ACA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 42.21Å b: 35.46Å c: 25.43Å
α: 90° β: 102.94° γ: 90°
R-values:
R R work R free
0.148 not available not available
Expression system: Not provided

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Citations

10 review citations

A player of many parts: the spotlight falls on thrombin's structure.
Stubbs et al. (1993)
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14 mentions without citation

Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking.
Hou et al. (2011)
13 more