› 2pmw

X-ray diffraction
2.3Å resolution

The Crystal Structure of Proprotein convertase subtilisin kexin type 9 (PCSK9)

Released:
DOI: 10.2210/pdb2pmw/pdb
PDB entry 2pmw coloured by chain, front view.
PDB entry 2pmw coloured by chain, side view.
PDB entry 2pmw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of PCSK9: a regulator of plasma LDL-cholesterol.
Piper DE, Jackson S, Liu Q, Romanow WG, Shetterly S, Thibault ST, Shan B, Walker NP
Structure 15 545-52 (2007)
PMID: 17502100

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185469 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Proprotein convertase subtilisin/kexin type 9 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.11 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q8NBP7 (Residues: 31-152; Coverage: 18%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains: Peptidase inhibitor I9
Structure domains: Peptidase S8 propeptide/proteinase inhibitor I9
Proprotein convertase subtilisin/kexin type 9 Chain: B
Molecule details ›
Chain: B
Length: 540 amino acids
Theoretical weight: 57.36 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q8NBP7 (Residues: 153-692; Coverage: 82%)
Gene names: NARC1, PCSK9, PSEC0052
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 63.106Å b: 70.709Å c: 150.693Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.232
Expression system: unidentified baculovirus

Quick links

Citations

51 review citations

PCSK9: a key modulator of cardiovascular health.
Seidah et al. (2014)
50 more

10 mentions without citation

Understanding the human antibody repertoire.
Rees AR. (2020)
9 more