› 2puu

X-ray diffraction
2.5Å resolution

Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea

Released:
DOI: 10.2210/pdb2puu/pdb
PDB entry 2puu coloured by chain, front view.
PDB entry 2puu coloured by chain, side view.
PDB entry 2puu coloured by chain, top view.
Source organism: Mus musculus
Entry author: Qian KC

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 348 amino acids
Theoretical weight: 39.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P47811 (Residues: 5-352; Coverage: 97%)
Gene names: Crk1, Csbp1, Csbp2, Mapk14
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand G2G 1 x G2G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 65.908Å b: 74.722Å c: 78.245Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.228 0.318
Expression system: Escherichia coli

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