› 2pz5

X-ray diffraction
2.4Å resolution

Crystal Structure of FGF Receptor 2 (FGFR2) Kinase Domain Harboring the Pathogenic N549T Mutation Responsible for Pfeiffer Syndrome

Released:
DOI: 10.2210/pdb2pz5/pdb
PDB entry 2pz5 coloured by chain, front view.
PDB entry 2pz5 coloured by chain, side view.
PDB entry 2pz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
Chen H, Ma J, Li W, Eliseenkova AV, Xu C, Neubert TA, Miller WT, Mohammadi M
Mol Cell 27 717-30 (2007)
PMID: 17803937

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149430 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 324 amino acids
Theoretical weight: 37.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 458-768; Coverage: 39%)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand SO4 4 x SO4
Ligand MG 4 x MG
Ligand ACP 2 x ACP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: P21212
Unit cell:
a: 105.043Å b: 114.474Å c: 64.347Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 0.254
Expression system: Escherichia coli

Quick links

Citations

44 review citations

Cell signaling by receptor tyrosine kinases.
Lemmon et al. (2010)
43 more

3 mentions without citation

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases.
Chen et al. (2017)
2 more