› 2pzx

X-ray diffraction
3.5Å resolution

Structure of the methuselah ectodomain with peptide inhibitor

Released:
DOI: 10.2210/pdb2pzx/pdb
PDB entry 2pzx coloured by chain, front view.
PDB entry 2pzx coloured by chain, side view.
PDB entry 2pzx coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor.
Ja WW, West AP, Delker SL, Bjorkman PJ, Benzer S, Roberts RW
Nat Chem Biol 3 415-9 (2007)
PMID: 17546039

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G-protein coupled receptor Mth Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 188 amino acids
Theoretical weight: 21.84 KDa
Source organism: Drosophila melanogaster
Expression system: unidentified baculovirus
UniProt:
  • Canonical: O97148 (Residues: 25-212; Coverage: 38%)
Gene names: CG6936, mth
Sequence domains: Methuselah N-terminus
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P42
Unit cell:
a: 94.233Å b: 94.233Å c: 173.833Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.376 0.376 0.407
Expression system: unidentified baculovirus

Quick links

Citations

11 review citations

Selection-based discovery of druglike macrocyclic peptides.
Passioura et al. (2014)
10 more

2 mentions without citation

Improvement of φ29 DNA polymerase amplification performance by fusion of DNA binding motifs.
de Vega et al. (2010)
1 more