› 2q05

X-ray diffraction
2.57Å resolution

Crystal structure of tyr/ser protein phosphatase from Vaccinia virus WR

Released:
DOI: 10.2210/pdb2q05/pdb
PDB entry 2q05 coloured by chain, front view.
PDB entry 2q05 coloured by chain, side view.
PDB entry 2q05 coloured by chain, top view.
Source organism: Vaccinia virus WR
Entry authors: Osipiuk J, Skarina T, Kagan O, Savchenko A, Edwards A, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dodecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139450 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dual specificity protein phosphatase OPG106 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 195 amino acids
Theoretical weight: 22.94 KDa
Source organism: Vaccinia virus WR
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07239 (Residues: 1-171; Coverage: 100%)
Gene names: H1L, OPG106
Sequence domains: Dual specificity phosphatase, catalytic domain
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 40 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P213
Unit cell:
a: 169.246Å b: 169.246Å c: 169.246Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.218
Expression system: Escherichia coli BL21(DE3)

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